Which type corresponds to Familial Dysbetalipoproteinemia?

• A. Type 1
• B. Type 2a
• C. Type 2b
• D. Type 3

Answer: (D)

Remnant clearance problem: Familial Dysbetalipoproteinemia occurs when remnants of chylomicrons and VLDL are not cleared efficiently because of the apoE2/E2 variant, leading to buildup of cholesterol- and triglyceride-rich remnants. This pattern is classified as Type III hyperlipoproteinemia. The defective apoE2/E2 interaction with receptors causes both cholesterol and triglycerides to rise together, often with elevated beta-VLDL and characteristic physical findings like xanthomas in the palms. Other types don’t fit this pattern: some involve isolated chylomicron or LDL elevations, or predominance of VLDL without the remnant accumulation seen here. So the type that corresponds to Familial Dysbetalipoproteinemia is the one described as remnant-removal disease (Type III).