Which tumor increases both AFP and hCG?

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Multiple Choice

Which tumor increases both AFP and hCG?

Explanation:
Tumor markers reflect the different cell types present in a tumor. AFP is mainly produced by yolk sac–type elements, while hCG comes from trophoblastic (choriocarcinoma) components. A non-seminomatous germ cell tumor can contain multiple histologies, such as both yolk sac (raising AFP) and choriocarcinoma (raising hCG). Because of this mixed composition, it can elevate both AFP and hCG, whereas hepatocellular carcinoma tends to raise AFP alone, choriocarcinoma tends to raise hCG alone, and a vague “gonadal tumor” label doesn’t specify marker patterns.

Tumor markers reflect the different cell types present in a tumor. AFP is mainly produced by yolk sac–type elements, while hCG comes from trophoblastic (choriocarcinoma) components. A non-seminomatous germ cell tumor can contain multiple histologies, such as both yolk sac (raising AFP) and choriocarcinoma (raising hCG). Because of this mixed composition, it can elevate both AFP and hCG, whereas hepatocellular carcinoma tends to raise AFP alone, choriocarcinoma tends to raise hCG alone, and a vague “gonadal tumor” label doesn’t specify marker patterns.

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