Which protein is NOT typically part of the alpha-2 globulin band in serum electrophoresis?

• A. A2-macroglobulin
• B. Haptoglobin
• C. Ceruloplasmin
• D. Albumin

Answer: (D)

In serum protein electrophoresis, proteins separate into bands by size and charge, creating distinct regions: albumin, alpha, beta, and gamma. The alpha-2 globulin region includes proteins such as haptoglobin, ceruloplasmin, and alpha-2-macroglobulin. Albumin, however, forms its own fastest-moving band and is not part of the alpha-2 region. Therefore, the protein that does not belong to the alpha-2 globulin band is albumin.