Which of the following is listed as an amphetamine-like substance?

• A. Piperazines
• B. Acetone
• C. Isopropanol
• D. Ethanol

Answer: (A)

Amphetamine-like substances are stimulants that affect monoamine systems in a way similar to amphetamine and can cross-react with common amphetamine screening tests. Piperazines are a class of synthetic stimulants (for example, benzylpiperazine) that produce stimulant effects by increasing monoamine activity, and they often trigger positive results on amphetamine immunoassays due to structural and functional similarity. The other substances—acetone, isopropanol, and ethanol—are solvents or simple alcohols without amphetamine-like pharmacology, so they aren’t described as amphetamine-like.