Which mediator is produced by the liver and mediates the action of growth hormone?

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Multiple Choice

Which mediator is produced by the liver and mediates the action of growth hormone?

Explanation:
Growth hormone mainly exerts its effects through a mediator produced by the liver. When GH acts on the liver, it stimulates the production of IGF-1 (insulin-like growth factor 1), also known as somatomedin C. IGF-1 then travels in the blood and binds to IGF-1 receptors on target tissues, especially growth plates in bones, promoting cell proliferation and growth, as well as other anabolic effects like protein synthesis. This is why IGF-1 is the primary mediator of GH’s actions rather than GH itself. The other substances listed don’t mediate GH effects: GH is the hormone released by the pituitary; ACTH stimulates cortisol production from the adrenal glands; PTH regulates calcium and phosphate metabolism.

Growth hormone mainly exerts its effects through a mediator produced by the liver. When GH acts on the liver, it stimulates the production of IGF-1 (insulin-like growth factor 1), also known as somatomedin C. IGF-1 then travels in the blood and binds to IGF-1 receptors on target tissues, especially growth plates in bones, promoting cell proliferation and growth, as well as other anabolic effects like protein synthesis. This is why IGF-1 is the primary mediator of GH’s actions rather than GH itself.

The other substances listed don’t mediate GH effects: GH is the hormone released by the pituitary; ACTH stimulates cortisol production from the adrenal glands; PTH regulates calcium and phosphate metabolism.

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