Which markers are associated with hepatic detoxification function?

• A. Bilirubin and Ammonia
• B. AST and ALT
• C. ALP and GGT
• D. Albumin and TP

Answer: (A)

Detoxification in the liver involves processing waste products so they can be eliminated in bile or urine. Bilirubin is a breakdown product of hemoglobin that the liver conjugates and excretes into bile; ammonia is produced from amino acid metabolism and is converted to urea for excretion. When detox pathways are impaired, bilirubin can accumulate and ammonia can rise, each signaling a problem with the liver’s ability to detoxify.

AST and ALT are enzymes that rise with liver cell injury. ALP and GGT point to problems with bile flow or cholestasis. Albumin and total protein reflect the liver’s synthetic function, not its detox processes.