Which lipoprotein has the lowest triglyceride content?

• A. HDL
• B. Chylomicrons
• C. LDL
• D. VLDL

Answer: (A)

Triglyceride content in lipoproteins tracks with their density and primary transport role. Chylomicrons carry dietary triglycerides and are very triglyceride-rich, while VLDL also contains lots of triglyceride produced by the liver. LDL is richer in cholesterol esters and proteins with relatively little triglyceride, and HDL is the densest particle with the smallest triglyceride core, reflecting its main role in reverse cholesterol transport rather than triglyceride transport. Therefore, the lipoprotein with the lowest triglyceride content is HDL.