Which lipoprotein has the lowest cholesterol content?

• A. HDL
• B. Chylomicrons
• C. LDL
• D. VLDL

Answer: (B)

The concept here is how the lipid makeup varies between lipoproteins. Chylomicrons are formed to transport dietary fats and are composed mostly of triglycerides, with only a small fraction as cholesterol esters. This triglyceride-dominant load means their overall cholesterol content is the lowest among the main lipoprotein classes. In contrast, HDL carries a large amount of cholesterol and cholesterol esters as it participates in reverse cholesterol transport, while LDL and VLDL contain more cholesterol than chylomicrons but less than HDL per particle. So, the lipoprotein with the lowest cholesterol content is chylomicrons.