Which LD isoenzyme is cold-labile?

Prepare for the Clinical Chemistry Numericals Test. Study with comprehensive questions, each with detailed explanations. Boost your confidence and excel on your exam!

Multiple Choice

Which LD isoenzyme is cold-labile?

Explanation:
Cold-labile means an enzyme loses activity when exposed to low temperatures. In lactate dehydrogenase, the five isoenzymes differ in subunit composition: LDH-1 (HHHH), LDH-2 (HHHM), LDH-3 (HHMM), LDH-4 (HMMM), and LDH-5 (MMMM). The more muscle-type M subunits an isoenzyme has, the more sensitive it is to cold-induced inactivation. LDH-5, composed entirely of M subunits, is the most cold-labile. So the correct choice is LDH-5.

Cold-labile means an enzyme loses activity when exposed to low temperatures. In lactate dehydrogenase, the five isoenzymes differ in subunit composition: LDH-1 (HHHH), LDH-2 (HHHM), LDH-3 (HHMM), LDH-4 (HMMM), and LDH-5 (MMMM). The more muscle-type M subunits an isoenzyme has, the more sensitive it is to cold-induced inactivation. LDH-5, composed entirely of M subunits, is the most cold-labile. So the correct choice is LDH-5.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy