Which hormone is increased in primary hypothyroidism and decreased in primary hyperthyroidism?

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Multiple Choice

Which hormone is increased in primary hypothyroidism and decreased in primary hyperthyroidism?

Explanation:
The pituitary-thyroid axis is governed by negative feedback. The pituitary releases TSH to stimulate the thyroid to make T3 and T4. When the thyroid is underproducing hormones (primary hypothyroidism), T3 and T4 fall, which reduces the feedback on the pituitary and causes TSH to rise as the body tries to boost thyroid output. When the thyroid is overactive (primary hyperthyroidism), T3 and T4 rise, sending stronger negative feedback and driving TSH down. So the hormone that increases in primary hypothyroidism and decreases in primary hyperthyroidism is TSH. (T3, T4, and FT3 show the opposite pattern: they are decreased in hypothyroidism and increased in hyperthyroidism.)

The pituitary-thyroid axis is governed by negative feedback. The pituitary releases TSH to stimulate the thyroid to make T3 and T4. When the thyroid is underproducing hormones (primary hypothyroidism), T3 and T4 fall, which reduces the feedback on the pituitary and causes TSH to rise as the body tries to boost thyroid output. When the thyroid is overactive (primary hyperthyroidism), T3 and T4 rise, sending stronger negative feedback and driving TSH down. So the hormone that increases in primary hypothyroidism and decreases in primary hyperthyroidism is TSH. (T3, T4, and FT3 show the opposite pattern: they are decreased in hypothyroidism and increased in hyperthyroidism.)

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