Which hormone acts as a negative feedback signal to inhibit growth hormone secretion?

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Multiple Choice

Which hormone acts as a negative feedback signal to inhibit growth hormone secretion?

Explanation:
IGF-1 is the negative feedback signal that inhibits growth hormone secretion. When growth hormone stimulates the liver to produce IGF-1, the circulating IGF-1 feeds back to the pituitary and hypothalamus to dampen GH release: it directly suppresses GHRH-driven stimulation at the pituitary and promotes somatostatin release from the hypothalamus. This feedback keeps GH levels in check as IGF-1 levels rise. Other hormones mentioned don’t serve this primary regulatory role. Cortisol, T3, and prolactin can influence the GH axis in various ways, but they are not the main negative feedback signal that directly inhibits GH secretion.

IGF-1 is the negative feedback signal that inhibits growth hormone secretion. When growth hormone stimulates the liver to produce IGF-1, the circulating IGF-1 feeds back to the pituitary and hypothalamus to dampen GH release: it directly suppresses GHRH-driven stimulation at the pituitary and promotes somatostatin release from the hypothalamus. This feedback keeps GH levels in check as IGF-1 levels rise.

Other hormones mentioned don’t serve this primary regulatory role. Cortisol, T3, and prolactin can influence the GH axis in various ways, but they are not the main negative feedback signal that directly inhibits GH secretion.

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