Which enzyme is the best marker for alcoholism?

• A. GGT
• B. ALP
• C. AST
• D. ALT

Answer: (A)

Chronic alcohol intake induces certain liver enzymes, and gamma-glutamyl transferase (GGT) is particularly sensitive to this effect. GGT levels rise with regular alcohol use and often remain elevated with ongoing consumption, making it a useful single indicator of alcohol use. In contrast, ALP mainly reflects bile duct or bone turnover, and AST/ALT indicate hepatocellular injury from a variety of causes. While the AST:ALT ratio can be higher in alcoholic liver disease, these transaminases are not specific for alcohol consumption on their own. Therefore, GGT best reflects alcohol use among the given enzymes, though it’s most informative when interpreted alongside other tests and clinical context.