Which drug is hepatotoxic?

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Multiple Choice

Which drug is hepatotoxic?

Explanation:
Hepatotoxicity from a drug often comes from the way the liver metabolizes it and handles reactive intermediates. Acetaminophen is the classic example: at normal doses it’s safe, but overdose floods the liver with a reactive metabolite called NAPQI. When glutathione stores are depleted, NAPQI binds to cellular proteins, causing oxidative damage and centrilobular hepatocellular necrosis that can lead to acute liver failure. Other drugs on the list can injure the liver in some cases, but acetaminophen’s dose‑dependent, well‑characterized hepatotoxic mechanism makes it the most notable example.

Hepatotoxicity from a drug often comes from the way the liver metabolizes it and handles reactive intermediates. Acetaminophen is the classic example: at normal doses it’s safe, but overdose floods the liver with a reactive metabolite called NAPQI. When glutathione stores are depleted, NAPQI binds to cellular proteins, causing oxidative damage and centrilobular hepatocellular necrosis that can lead to acute liver failure. Other drugs on the list can injure the liver in some cases, but acetaminophen’s dose‑dependent, well‑characterized hepatotoxic mechanism makes it the most notable example.

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