Which chemical inhibitor inhibits Bone and Liver isoenzymes?

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Multiple Choice

Which chemical inhibitor inhibits Bone and Liver isoenzymes?

Explanation:
In studies of alkaline phosphatase isoenzymes, selective inhibitors help distinguish bone-origin enzyme from liver-origin enzyme. Levamisole is known to preferentially inhibit the bone isoenzyme of alkaline phosphatase, while the liver isoenzyme remains largely active. This difference allows a levamisole inhibition test to identify whether elevated ALP activity comes from bone or liver tissue. The other options either act only as general denaturants (3M urea), or are not used for selective ALP isoenzyme discrimination (phenylalanine, leucine).

In studies of alkaline phosphatase isoenzymes, selective inhibitors help distinguish bone-origin enzyme from liver-origin enzyme. Levamisole is known to preferentially inhibit the bone isoenzyme of alkaline phosphatase, while the liver isoenzyme remains largely active. This difference allows a levamisole inhibition test to identify whether elevated ALP activity comes from bone or liver tissue. The other options either act only as general denaturants (3M urea), or are not used for selective ALP isoenzyme discrimination (phenylalanine, leucine).

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