Which cell type secretes LH and FSH?

• A. Lactotrophs
• B. Somatotrophs
• C. Gonadotrophs
• D. Thyrotrophs

Answer: (C)

LH and FSH are gonadotropins produced by the anterior pituitary. The cells responsible for secreting both of these hormones are called gonadotrophs. Other pituitary cell types have distinct roles: lactotrophs make prolactin, somatotrophs make growth hormone, and thyrotrophs make TSH. Gonadotrophs release LH and FSH in response to pulsatile GnRH from the hypothalamus, a pattern that’s essential for proper gonadal function. These hormones share a common alpha subunit but have different beta subunits, giving them specific actions on the gonads. In females, LH promotes ovulation and supports the corpus luteum, while FSH drives follicle development and estrogen production; in males, FSH supports spermatogenesis and LH stimulates testosterone production. Negative feedback from sex steroids and inhibin helps regulate their release.