Which cell type secretes ACTH?

• A. Lactotrophs
• B. Somatotrophs
• C. Corticotrophs
• D. Thyrotrophs

Answer: (C)

ACTH is produced by corticotrophs in the anterior pituitary. These cells respond to CRH from the hypothalamus and release ACTH, which then acts on the adrenal cortex to stimulate cortisol production. The other pituitary cell types secrete different hormones: lactotrophs release prolactin (milk production), somatotrophs release growth hormone (growth and metabolism), and thyrotrophs release TSH (stimulates the thyroid). Understanding which cells make ACTH helps connect pituitary function to adrenal hormone regulation.