Which Aldolase isoenzyme is primarily located in brain tissue?

• A. Aldolase C
• B. Aldolase A
• C. Aldolase B
• D. Aldolase D

Answer: (A)

Aldolase C is the isoenzyme enriched in brain tissue. Isoforms of aldolase arise from different genes and show tissue-specific expression to meet distinct metabolic needs. In muscle and red blood cells, aldolase A handles glycolysis, while in liver and kidney aldolase B dominates. In neurons and brain tissue, aldolase C is expressed at higher levels, aligning with the brain’s energetic demands. Aldolase D isn’t a standard human isoform, so it isn’t relevant here. So the brain’s primary aldolase isoenzyme is aldolase C.