What percentage of testosterone is bound to SHBG?

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Multiple Choice

What percentage of testosterone is bound to SHBG?

Explanation:
Testosterone in the blood is carried mainly by proteins, with SHBG binding it tightly and albumin binding it more loosely, leaving only a small free fraction. In typical physiology, about 60% of circulating testosterone is bound to SHBG, around 38–40% is bound to albumin, and roughly 1–3% remains free. Because SHBG binding is strong, the SHBG-bound pool is the largest single bound fraction. So the percentage bound to SHBG is about 60%—the 45% figure isn’t the standard value, though actual numbers can vary slightly with SHBG levels and individual physiology. The key concept is that SHBG carries the majority of testosterone in the bound form, with a small free portion driving bioavailability.

Testosterone in the blood is carried mainly by proteins, with SHBG binding it tightly and albumin binding it more loosely, leaving only a small free fraction. In typical physiology, about 60% of circulating testosterone is bound to SHBG, around 38–40% is bound to albumin, and roughly 1–3% remains free. Because SHBG binding is strong, the SHBG-bound pool is the largest single bound fraction. So the percentage bound to SHBG is about 60%—the 45% figure isn’t the standard value, though actual numbers can vary slightly with SHBG levels and individual physiology. The key concept is that SHBG carries the majority of testosterone in the bound form, with a small free portion driving bioavailability.

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