What percent of T4 is bound to albumin in circulation?

Prepare for the Clinical Chemistry Numericals Test. Study with comprehensive questions, each with detailed explanations. Boost your confidence and excel on your exam!

Multiple Choice

What percent of T4 is bound to albumin in circulation?

Explanation:
Thyroxine in the blood is carried mainly by binding proteins, which keeps most of the hormone in reserve and slows its elimination. The strongest binder is thyroxine-binding globulin, which holds the majority of T4. Albumin also binds T4, but with lower affinity, so it carries a smaller portion even though it’s plentiful in plasma. Because of this balance, roughly one-tenth of circulating T4 is bound to albumin, with the rest bound to other proteins like transthyretin and the majority to TBG, and only a tiny fraction remains free to act on tissues. So about 10% bound to albumin is the best, widely used estimate.

Thyroxine in the blood is carried mainly by binding proteins, which keeps most of the hormone in reserve and slows its elimination. The strongest binder is thyroxine-binding globulin, which holds the majority of T4. Albumin also binds T4, but with lower affinity, so it carries a smaller portion even though it’s plentiful in plasma. Because of this balance, roughly one-tenth of circulating T4 is bound to albumin, with the rest bound to other proteins like transthyretin and the majority to TBG, and only a tiny fraction remains free to act on tissues. So about 10% bound to albumin is the best, widely used estimate.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy