What is the process of testing and adjusting an analyzer's readout for correlation with a standard called?

• A. Calibration
• B. Validation
• C. Verification
• D. Standardization

Answer: (A)

Calibration is the process of testing and adjusting an analyzer’s readout to match a known standard. In practice, you measure standards with known concentrations, compare what the instrument shows to their true values, and make any needed adjustments so the readout aligns with the standard. Often this yields a calibration curve that defines how the instrument should respond across the measurement range. After calibration, you recheck with standards to confirm accuracy throughout the range. This is different from validation (does the method work for its intended clinical purpose), verification (does the instrument meet predefined specifications), and standardization (establishing uniform methods and reference materials across labs).