What is a urinary metabolite of progesterone?

• A. Pregnanediol
• B. Pregnenolone
• C. Allopregnanolone
• D. 4-androstenedione

Answer: (A)

Progesterone is processed in the body to several downstream products, and the major product excreted in urine is pregnanediol (often measured as pregnanediol glucuronide). This metabolite reflects luteal activity and progesterone clearance. The other options are not the principal urinary end products of progesterone: pregnenolone is an upstream precursor, allopregnanolone is a reduced, neuroactive form not the main urinary marker, and 4-androstenedione is an androgen from separate pathways. Therefore, pregnanediol is the correct urinary metabolite of progesterone.