What are the two major sources of ACP?

• A. Red blood cells and Prostate
• B. Liver and Bone
• C. Kidney and Pancreas
• D. Muscle and Bone

Answer: (A)

Two major sources supply acid phosphatase activity in serum: the prostate gland and red blood cells. Prostate acid phosphatase comes from prostatic tissue and enters circulation, especially in prostate-related conditions, while red blood cells contain cytosolic acid phosphatase that contributes to serum activity—often revealed or amplified by hemolysis or high RBC turnover. Other tissues like liver or bone do contain ACP, but their contribution to circulating ACP is comparatively small, so they’re not the primary sources in standard measurements.