Triose phosphate isomerase is categorized under which enzyme class?

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Multiple Choice

Triose phosphate isomerase is categorized under which enzyme class?

Explanation:
Enzyme classification is based on the type of chemical transformation an enzyme catalyzes. Isomerases perform intramolecular rearrangements, converting one isomer into another without adding or removing atoms. Triose phosphate isomerase does exactly that: it reversibly converts dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis by rearranging the atoms within the molecule, not by oxidation/reduction, group transfer, or joining molecules. That internal rearrangement fits the definition of an isomerase. Other classes would involve redox changes, transferring a functional group between molecules, or ligating two molecules, none of which describe this reaction. (It's categorized as EC 5.3.1.5.)

Enzyme classification is based on the type of chemical transformation an enzyme catalyzes. Isomerases perform intramolecular rearrangements, converting one isomer into another without adding or removing atoms. Triose phosphate isomerase does exactly that: it reversibly converts dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis by rearranging the atoms within the molecule, not by oxidation/reduction, group transfer, or joining molecules. That internal rearrangement fits the definition of an isomerase. Other classes would involve redox changes, transferring a functional group between molecules, or ligating two molecules, none of which describe this reaction. (It's categorized as EC 5.3.1.5.)

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