Kasha disease is a deficiency of which trace element?

• A. Selenium
• B. Zinc
• C. Iodine
• D. Manganese

Answer: (A)

Keshan disease is a selenium deficiency–related cardiomyopathy. Selenium is a trace element needed for selenoproteins such as glutathione peroxidase, which protects heart muscle by neutralizing reactive oxygen species. When selenium intake is inadequate, oxidative damage accumulates in cardiac cells, leading to myocarditis and a dilated cardiomyopathy pattern characteristic of this condition. Regions with low soil selenium historically saw outbreaks, and supplementation helps prevent it. Zinc, iodine, and manganese do not cause this disease.