Intracellularly, which LD isoenzyme is more abundant?

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Multiple Choice

Intracellularly, which LD isoenzyme is more abundant?

Explanation:
LDH isoenzymes differ by the subunits they contain, and the tissue that has more of a given subunit will express the corresponding isoform more. The heart and red blood cells are rich in the heart-type subunit (H), so the LDH isoenzyme with four H subunits, LDH-1, is the most abundant inside these cells. This form is well suited for aerobic metabolism, efficiently converting lactate to pyruvate for entry into the mitochondria to fuel energy production, which fits the heart’s energy needs. Hence, intracellularly, LDH-1 is the predominant isoenzyme.

LDH isoenzymes differ by the subunits they contain, and the tissue that has more of a given subunit will express the corresponding isoform more. The heart and red blood cells are rich in the heart-type subunit (H), so the LDH isoenzyme with four H subunits, LDH-1, is the most abundant inside these cells. This form is well suited for aerobic metabolism, efficiently converting lactate to pyruvate for entry into the mitochondria to fuel energy production, which fits the heart’s energy needs. Hence, intracellularly, LDH-1 is the predominant isoenzyme.

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