In the synthesis of thyroid hormones, which component is produced first?

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Multiple Choice

In the synthesis of thyroid hormones, which component is produced first?

Explanation:
Thyroglobulin is produced first. Thyroid hormone synthesis starts with making thyroglobulin, a large glycoprotein made by thyroid follicular cells and secreted into the follicular lumen where it forms part of the colloid. Iodide is then taken up and organified on tyrosine residues of thyroglobulin to form MIT and DIT, which couple to generate the hormones T3 and T4 still attached to thyroglobulin. After proteolytic digestion inside lysosomes, free T3 and T4 are released. T2 and other products come later in the processing, but the very first component created is thyroglobulin.

Thyroglobulin is produced first. Thyroid hormone synthesis starts with making thyroglobulin, a large glycoprotein made by thyroid follicular cells and secreted into the follicular lumen where it forms part of the colloid. Iodide is then taken up and organified on tyrosine residues of thyroglobulin to form MIT and DIT, which couple to generate the hormones T3 and T4 still attached to thyroglobulin. After proteolytic digestion inside lysosomes, free T3 and T4 are released. T2 and other products come later in the processing, but the very first component created is thyroglobulin.

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