In hemolytic anemia (HA), how are G6PD and PK levels affected?

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Multiple Choice

In hemolytic anemia (HA), how are G6PD and PK levels affected?

Explanation:
G6PD and PK are enzymes located inside red blood cells, not in plasma. In hemolytic anemia, many red cells are destroyed, so there are fewer intact red cells carrying these enzymes. Because standard tests measure enzyme activity in red blood cells or their lysates, the overall activity you detect decreases as the red cell mass declines. (If you happened to measure these enzymes in plasma, you might see a temporary increase from enzyme release during lysis, but that’s not how these tests are typically interpreted.) So, the observed levels of G6PD and PK in this context are decreased.

G6PD and PK are enzymes located inside red blood cells, not in plasma. In hemolytic anemia, many red cells are destroyed, so there are fewer intact red cells carrying these enzymes. Because standard tests measure enzyme activity in red blood cells or their lysates, the overall activity you detect decreases as the red cell mass declines. (If you happened to measure these enzymes in plasma, you might see a temporary increase from enzyme release during lysis, but that’s not how these tests are typically interpreted.) So, the observed levels of G6PD and PK in this context are decreased.

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