In assessing CRP for CHD and stroke risk, how should samples be measured?

• A. A single specimen at presentation
• B. Average from two specimens 2 weeks apart
• C. Daily samples for a week
• D. Two samples 1 day apart

Answer: (B)

CRP rises with inflammation, but for cardiovascular risk you want to know about persistent, low-grade inflammation rather than a temporary spike from an infection or injury. A single measurement can be misleading because it might reflect an acute event or transient factors. Measuring two specimens spaced about two weeks apart and averaging them provides a more stable estimate of the baseline CRP level, reducing the impact of short-term fluctuations and better indicating long-term risk. The other options either rely on a one-time snapshot or involve unnecessary sampling without improving reliability.