Hyperprogesteronemia is associated with which menstrual outcome?

• A. Amenorrhea
• B. Menorrhagia
• C. Oligomenorrhea
• D. Anovulation

Answer: (A)

High progesterone keeps the endometrium in a secretory, non-shedding state. When progesterone remains elevated for a prolonged period—such as during pregnancy, when the placenta sustains high progesterone production—the endometrium is maintained and there is no withdrawal bleed. Since menstrual bleeding occurs only after progesterone falls, consistently high levels lead to absence of menses, i.e., amenorrhea. In contrast, low or fluctuating progesterone is more often linked to ovulatory irregularities and other menstrual patterns.