Hashimoto's thyroiditis is associated with antibodies including anti-thyroglobulin, anti-TPO, and anti-microsomal antibodies. Which option lists these antibodies?

• A. Anti-thyroglobulin antibodies
• B. Anti-TPO antibodies
• C. Anti-microsomal antibodies
• D. Anti-thyroglobulin, Anti-TPO, and anti-microsomal antibodies

Answer: (D)

Hashimoto's thyroiditis is an autoimmune thyroid disease where the immune system creates antibodies targeting thyroid components. The antibodies commonly found include anti-thyroglobulin and anti-thyroid peroxidase (anti-TPO). The term anti-microsomal antibodies is an older name for anti-TPO, since microsomal antigens refer to the thyroid peroxidase enzyme. Because these conditions can involve multiple such antibodies, the description that includes anti-thyroglobulin, anti-TPO, and anti-microsomal antibodies best reflects what can be present in Hashimoto's. Anti-TPO is the most sensitive and frequently detected, but the presence of anti-thyroglobulin and anti-microsomal (anti-TPO) antibodies is also consistent with the disease.