First abnormality and recovery seen in hyperthyroidism is which index?

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Multiple Choice

First abnormality and recovery seen in hyperthyroidism is which index?

Explanation:
In hyperthyroidism, the earliest biochemical change is an increase in T3 because peripheral conversion of T4 to T3 rises and T3 is the more active hormone. This makes T3 the first index to become abnormal. Since T3 has a shorter half-life than T4, it also returns to normal sooner as treatment takes effect, so T3 is the first to recover. TSH tends to stay normal or only drop after T3/T4 rise, and T4 can stay normal in the very early stage, so they are not the earliest indicators. Free T3 behaves similarly to total T3, but the question points to the initial change and recovery pattern for the conventional index, which is T3.

In hyperthyroidism, the earliest biochemical change is an increase in T3 because peripheral conversion of T4 to T3 rises and T3 is the more active hormone. This makes T3 the first index to become abnormal. Since T3 has a shorter half-life than T4, it also returns to normal sooner as treatment takes effect, so T3 is the first to recover. TSH tends to stay normal or only drop after T3/T4 rise, and T4 can stay normal in the very early stage, so they are not the earliest indicators. Free T3 behaves similarly to total T3, but the question points to the initial change and recovery pattern for the conventional index, which is T3.

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