Among lipoproteins, which has the highest cholesterol content?

• A. LDL
• B. VLDL
• C. HDL
• D. CM

Answer: (A)

Cholesterol distribution among lipoproteins varies by their primary cargo. LDL stands out as the main carrier of cholesterol in plasma. It is rich in cholesterol esters and is formed from VLDL after triglyceride removal, delivering cholesterol to tissues via LDL receptors. Other particles are mainly triglyceride-rich—chylomicrons and VLDL carry most of their mass as triglycerides—while HDL’s role is to scavenge cholesterol from tissues and return it to the liver rather than serving as the primary cholesterol carrier in circulation. Because of its cholesterol-rich composition and its dominance in total plasma cholesterol, the lipoprotein with the highest cholesterol content is LDL.